Discover the latest highlights from our team. Browse the news items below and follow the links to our newsletters for full stories on events, publications, and more. News and events 2025 New paper: Corley, J. et al. (2025). Dietary exposures and risk of anxiety and depression symptoms in the Lothian Birth Cohort 1936: A cohort-level GLAD Project analysis. Wellcome Open Research. https://doi.org/10.12688/wellcomeopenres.24950.1Dr Janie Corley provides expert commentary for Environmental Health NewsNew paper: Moodie, J. E. et al. (2025). Brain maps of general cognitive functioning: Neuroimaging and neurobiological signatures. Translational Psychiatry. https://doi.org/10.1038/s41398-025-03617-8New paper: Deary, I. J. et al. (2025). Effect sizes of APOE e4 on the same general cognitive ability test taken by the same people from age 11 to age 90: The Lothian Birth Cohorts 1921 and 1936. Molecular Psychiatry. https://doi.org/10.1038/s41380-025-03274-9New paper: Moodie, J. E. et al. (2025). Cognitive dedifferentiation in later life: Longitudinal findings from the Lothian Birth Cohort 1936. https://doi.org/10.1093/geronb/gbaf189New paper: Biesbroek, J. M. et al. (2025). Signature white matter hyperintensity locations associated with vascular risk factors derived from 15 653 individuals. Stroke. https://doi.org/10.1161/STROKEAHA.125.051159October 10: Dr Barbora Skarabela joins a panel at the Standing Up for Science: Voice of Young Science workshop, organised by Sense about ScienceSeptember 27: LBC team contributes to the Doors Open Day at EFINew paper: Shen, X., et al. (2025). A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison. Epidemiology. https://doi.org/10.1101/2023.10.27.23297630September 16: Starting a second year of Healthy Brains at Boroughmuir High SchoolNew paper: Foote, I. F., et al. (2025). Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling. Nature Genetics. https://doi.org/10.1038/s41588-025-02269-New paper: Conole, E. L. S. et al. (2025). Epigenetic clocks and DNA methylation biomarkers of brain health and disease. Nature Reviews Neurology. https://doi.org/10.1038/s41582-025-01105-7New paper: Fürtjes, A. E. et al. (2025). Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI. Nature Communications. https://doi.org/10.1038/s41467-025-61978-6New paper: Malkowski, O. S. (2025). Correlates and determinants of physical activity among older adults of lower versus higher socio-economic status: A systematic review and meta-analysis. International Journal of Behavioral Nutrition and Physical Activity. https://doi.org/10.1186/s12966-025-01775-yJune 17: Celebrating Wave 7 data completion with the LBC participants and guests at reunion eventRead about the latest updates in the June issue of the Disconnected Mind NewsletterMay 10: LBC team joins IntoUniversity and the University's Widening Participation team for a family workshop on Psychology and Healthy Brains at Old CollegeThe BBC Future explores the benefits of gardening How gardening can help you live better for longer, citing Dr Janie Corley's study with LBC dataENIGMA-Chronic Pain working group, a worldwide initiative pooling neuroimaging and clinical data from thousands of individuals, including the LBCs, on the National Public Radio (NPR) How to cope with chronic painNew paper: Chamberlain, J. D. et al. (2025). Development and validation of an epigenetic signature of allostatic load. Bioscience Reports, 45(04), 247–262. https://doi.org/10.1042/BSR20241663New paper: Perez-Correa, J.-F. et al. (2025). Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age. Genome Biology. https://doi.org/10.1186/s13059-025-03562-1New paper: Nagarajan, P. et al. (2025). A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations. Molecular Psychiatry. https://doi.org/10.1038/s41380-025-02954-wNew paper: Chybowska, A. D. (2025). A blood- and brain-based EWAS of smoking. Nature Communications. https://doi.org/10.1101/2024.05.21.24307663New paper: Park, W. et al. (2025). AI-based deformable hippocampal mesh reflects hippocampal morphological characteristics in relation to cognition in healthy older adults. NeuroImage. https://doi.org/10.1016/j.neuroimage.2025.121145Professor Simon Cox offers expertise on reaction times for BBC Future: Quick home health tests: Check your reaction timesMarch 28: Dr Janie Corley talks about healthy brain ageing at the Heart of Newhaven CommunityMarch 21: LBC team joins the Castlebrae Community Science FestivalMarch 12: Celebrating Brain Awareness Week with P7 pupils at St Francis Primary SchoolRead about the latest LBC updates in the March issue of the Disconnected Mind NewsletterNew paper: Davyson, E. et al. (2025). Insights from a methylome-wide association study of antidepressant exposure. Nature Communications. https://doi.org/10.1038/s41467-024-55356-xThe Guardian features LBC study on air pollution: How dementia could be linked to air pollution in early lifeNew paper: Jutila, O. E. et al. (2025). Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936. Environmental Epidemiology. https://doi.org/10.1097/EE9.0000000000000355New paper: de Kort, F. A. S. et al. (2025). Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2024.11.006New paper: Bernabeu, E. et al. (2025). Blood-based epigenome-wide association study and prediction of alcohol consumption. Clinical Epigenetics. https://doi.org/10.1186/s13148-025-01818-yNew paper: Smith, H. M. et al. (2025). DNA methylation-based predictors of metabolic traits in Scottish and Singaporean cohorts. The American Journal of Human Genetics, 112(1), 106–115. https://doi.org/10.1016/j.ajhg.2024.11.012Drs David Hill and Charley Xia discuss their work exploring links between poverty and mental illness in a PPLS podcast Newsletters Disconnected Mind Newsletters bring the latest updates about the Lothian Birth Cohorts. Each issue is published every three months and includes new information about our team, research and events. Browse through the latest issue: Disconnected Mind Newsletter 70 (June 2025).Click here for previous issuesEmail us at lbc.ke@ed.ac.uk if you are interested in being added to our mailing list and we will email you a copy of the Disconnected Mind Newsletter when a new issue becomes available.Each December we also send out Christmas Newsletters to the LBC participants with an overview of the study's news, including staff updates, publication highlights, and how we've shared our findings with wider audiences. This article was published on 2025-11-21
