Summary data and other resources

On this page you can access GWAS (Genome-Wide Association Study) and EWAS (Epigenome-Wide Association Study) summary data from our published research, find code for modelling LBC1936 longitudinal cognitive ability data and other resources (a link to a guide for systematic reviews for studies in older people).

GWAS and EWAS datasets (in alphabetical order, by first author)

Davies, G. et al. (2016) dataset supporting Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151). Molecular Psychiatry.

Davies, G. et al. (2018) dataset (UK Biobank results) supporting Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications.

Davies, G. et al. (2018) dataset (Open dataset summary results) supporting Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications.

Deary V. et al. (2018) dataset supporting Genetic contributions to self-reported tiredness. Molecular Psychiatry.

de la Fuente, J. et al. (2020) dataset supporting A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data. Nature Human Behaviour

Hagenaars, S.P., et al. (2017) dataset supporting Genetic prediction of male pattern baldness. PLOS Genetics.

Harris, S.E. et al. (2017) dataset supporting Molecular genetic contributions to self-rated health. International Journal of Epidemiology.

Hill, W.D. et al. (2016) dataset supporting Molecular genetic contributions to social deprivation and household income in UK Biobank. Current Biology.

Hill, W.D. et al. (2019) dataset supporting Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income. Nature Communications.

Hill, W.D. et al. (2019) dataset supporting Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life. Molecular Psychiatry.

Hillary, F.R. et al. (2019) GWAS dataset supporting Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936. Nature Communications.

Hillary, F.R. et al. (2019) EWAS dataset supporting Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936. Nature Communications.

Luciano, M. et al. (2018) dataset supporting Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism. Nature Genetics.

Luciano, M. et al. (2019) dataset supporting The influence of X chromosome variants on trait neuroticism. Molecular Psychiatry.

Marioni, R. et al. (2018) dataset supporting GWAS on family history of Alzheimer's disease. Translational Psychiatry.

Software

Software described in Deary, I.J. et al. (2011): A free, easy-to-use, computer-based simple and four-choice reaction time programme: The Deary-Liewald reaction time task. Behavior Research Methods

Code

The LBC team have developed code to model cognitive ability level and change in the LBC1936. The code is available for researchers to use:

Lothian Birth Cohorts longitudinal g models

Modelling cognitive ability level and change in the LBC1936

R code for factor-of-curves model

Mplus code for factor-of-curves model

Code for Conte et al. (2022) published in Psychological Science

Other resources

Shenkin, S.D. et al. (2017). Systematic reviews: guidance relevant for studies of older people. Age and Ageing.

This is a free access article with general guidance and tips for those interested in conducting systematic reviews and meta-analysis on healthcare in older people.