2020

Articles with Lothian Birth Cohorts data published in 2020, organised in alphabetical order by first author. Each article title is linked to the publication journal. Most of the articles are Open Access and free to view.

Alonso, N. et al. Loss‐of‐function mutations in the ALPL gene presenting with adult onset osteoporosis and low serum concentrations of total alkaline phosphatase. Journal of Bone and Mineral Research

Altschul, D. M. and Deary, I. J. Playing analog games is associated with reduced declines in cognitive function: a 68 year longitudinal cohort study. The Journals of Gerontology: Series B

Altschul, D. et al. Generational differences in loneliness and its psychological and sociodemographic predictors: an exploratory and confirmatory machine learning study. Psychological Medicine

Altschul, D. M. et al. Blood pressure and cognitive function across the eighth decade: a prospective study of the Lothian Birth Cohort 1936. BMJ Open

Aribisala, B. S. et al. Sleep and brain morphological changes in the eighth decade of life. Sleep Medicine

Armstrong, N. J. et al. Common genetic variation indicates separate causes for periventricular and deep white matter hyperintensities. Stroke

Ballerini, L. et al. Computational quantification of brain perivascular space morphologies: associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936. NeuroImage: Clinical

Beaudet, G. et al. Age-related changes of peak width skeletonized mean diffusivity (PSMD) across the adult life span: a multi-cohort study. Frontiers in Psychiatry

Biton, A. et al. Polygenic architecture of human neuroanatomical diversity. Cerebral Cortex

Cadar, D. et al. The long arm of childhood intelligence on terminal decline: evidence from the Lothian Birth Cohort 1921. Psychology and Aging

Colicino, E. et al. Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals. Aging

Corley, J. et al. Dietary patterns, cognitive function, and structural neuroimaging measures of brain aging. Experimental gerontology

Corley, J. et al. Dietary patterns and trajectories of global and domain-specific cognitive decline in the Lothian Birth Cohort 1936. British Journal of Nutrition

Corley, J. Adherence to the MIND diet is associated with 12-year all-cause mortality in older adults. Public Health Nutrition

Cuellar-Partida, G. et al. Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour

de las Fuentes, L. et al. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry

Erzurumluoglu, A. M. et al. Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Molecular Psychiatry

Gale, C. et al. Physical frailty and decline in general and specific cognitive abilities: the Lothian Birth Cohort 1936. Journal of Epidemiology and Community Health

Graham, E. K. et al. Is healthy neuroticism associated with health behaviors? A coordinated integrative data analysis. Collabra: Psychology

Graham, E. K. et al. Trajectories of big five personality traits: A coordinated analysis of 16 longitudinal samples. European Journal of Personality

Grasby, K. L. et al. The genetic architecture of the human cerebral cortex. Science

Harris, S. E. et al. Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age. Nature Communications

Hillary, R.F. et al. An epigenetic predictor of death captures multi-modal measures of brain health. Molecular Psychiatry

Hillary, R. F. et al. Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults. Genome Medicine

Knol, M. J.et al.  Association of common genetic variants with brain microbleeds: a genome-wide association study. Neurology

Li, S. et al. Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples. Genome Medicine

Lund, J.B. et al. Weighted gene co-regulation network analysis (WGCNA) of promoter DNA methylation on all-cause mortality in old-aged birth cohorts finds modules of high-risk associated biomarkers. The Journals of Gerontology: Series A

Lund, J. et al. Age‐dependent DNA methylation patterns on the Y chromosome in elderly males.

Aging Cell

Ma, J. et al. Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality. Circulation Genomic and Precision Medicine

Madole, J. W. et al. Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines. Biological Psychiatry

McLachlan, K. J. et al. Attitudes to ageing, biomarkers of ageing and mortality: the Lothian Birth Cohort 1936. Journal of Epidemiology and Community Health

Moodie, J. E. et al. Fluctuating asymmetry in brain structure and general intelligence in 73-year-olds. Intelligence

Okely, J. et al. Change in Physical Activity, Sleep Quality, and Psychosocial Variables during COVID-19 Lockdown: Evidence from the Lothian Birth Cohort 1936. International Journal of Environmental Research and Public Health

Okely, J. and Deary, I. J. Associations between declining physical and cognitive functions in the Lothian Birth Cohort 1936. The Journals of Gerontology

Ritchie, S. J. et al. Polygenic predictors of age-related decline in cognitive ability. Molecular Psychiatry

Sargurupremraj, M. et al. Cerebral small vessel disease genomics and its implications across the lifespan. Nature Communications

Seeboth, A. et al. DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936. Clinical Epigenetics

Shin, J. et al. Global and regional development of the human cerebral cortex: molecular architecture and occupational aptitudes. Cerebral Cortex

Sibbett, R. et al. DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: A study of the Lothian Birth Cohort 1921. BMC Psychiatry

Stevenson, A. J. et al. Characterisation of an inflammation-related epigenetic score and its association with cognitive ability. Clinical Epigenetics

Surendran, P. et al. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics

Taylor, A. M. et al. Associations between Brief Resilience Scale scores and ageing-related domains in the Lothian Birth Cohort 1936. Psychology and Aging

Toombs, J. et al. Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Stem Cell Research

Trejo Banos, D. et al. Bayesian reassessment of the epigenetic architecture of complex traits. Nature Communications

Turiano, N. A. et al. Is healthy neuroticism associated with longevity? A coordinated integrative data analysis. Collabra: Psychology

Valdes Hernandez, M.C. et al. Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: effect on cognition and associations with mineral deposition. Brain Imaging and Behavior.

Welstead, M. et al. Inflammation as a risk factor for the development of frailty in the Lothian Birth Cohort 1936. Experimental Gerontology